AMP‐activated protein kinase (AMPK) is an evolutionarily conserved cellular switch that activates catabolic pathways and turns off anabolic processes. In this way, AMPK activation can restore the perturbation of cellular energy levels. In physiological situations, AMPK senses energy deficiency (in the form of an increased AMP/ATP ratio), but it is also activated by metabolic insults, such as glucose or oxygen deprivation. Metformin, one of the most widely prescribed anti‐diabetic drugs, exerts its actions by AMPK activation. However, while the functions of (...) AMPK as a metabolic regulator are fairly well understood, its actions in neuronal cells only recently gained attention. This review will discuss newly emerged functions of AMPK in neuroprotection and neurodegeneration. Additionally, recent views on the role of AMPK in autophagy, an important catabolic process that is also involved in neurodegeneration and cancer, will be highlighted. (shrink)

Objectives: Childhood cancer is a life-threatening disease that poses significant challenges to the life of the diagnosed child and his/her family members. Based on the ABCX-model, the aim of the current study was to explore the association between family functioning, cancer appraisal and the individual adjustment of patients, parents and siblings. Method: Participants were 60 children with leukemia or non-Hodgkin lymphoma, 172 parents and 78 siblings (115 families). Time since diagnosis varied from zero to 33 months. Patients, parents and siblings (...) completed the Family Environment Scale, Perceived Stress Scale, Situation-Specific Emotional Reactions Questionnaire and Pediatric Quality of Life Inventory/Maudsley Marital Questionnaire. Results: Family functioning and the appraisal of the cancer diagnosis proved to be related to patients’, parents’ and siblings’ cancer-related emotions and quality of life post-diagnosis. In addition, family members differed in their perception of some family functioning domains, the appraisal of the cancer diagnosis, positive feelings and quality of life. Discussion: Our findings led to the conclusion that family functioning and the appraisal of the cancer diagnosis are important for the individual adjustment of patients, parents and siblings when facing a diagnosis of cancer in the child. Differences across members within one family speak to the need of screening all family members and intervening at the level of the family unit. (shrink)

Objectives: Pediatric cancer is a life-threatening disease that poses significant challenges to the life of all family members (diagnosed child, parents, siblings) and the family as a whole. To date, limited research has investigated family adjustment when facing pediatric cancer. The aim of the current longitudinal study was to explore the predictive role of protective factors at the individual (parental psychological flexibility), intrafamilial (dyadic coping) and contextual level (network support) in explaining family adjustment as perceived by parents of children with (...) leukemia or non-Hodgkin lymphoma. In addition, we were interested to see whether these protective factors could be predictive for family adjustment at a later time point. Method: Participants were 70 mothers and 53 fathers (80 families) of children with leukemia or non-Hodgkin lymphoma. Mean time since diagnosis was 5.26 (T1) and 18.86 (T2) months post-diagnosis. Parents completed the Acceptance and Action Questionnaire II (to assess psychological flexibility), Dyadic Coping Inventory, a network support questionnaire, Impact on Family Scale and the Family Adjustment Scale. Both concurrent and prospective association models were tested. Results: Psychological flexibility, dyadic coping and network support proved to be cross-sectionally and positively related to parents’ perception of family adjustment post-diagnosis; psychological flexibility and dyadic coping proved to predict better family adjustment over time. Conclusions: Our findings led to the conclusion that protective factors at all three levels (individual, intrafamilial and contextual) are important for explaining family adjustment as perceived by parents facing a diagnosis of cancer in their child. Interventions targeting the individual, couple, as well as family level are warranted to enhance family adjustment. (shrink)

Ziel des Beitrages ist, die Bedeutung der Mysterien für das Denken des jungen Nietzsche, der unauffällig, aber dezidiert die Kernbegriffe seines Philosophierens - das Apollinische und das Dionysische, die Tragödie, die ästhetische Rechtfertigung der Welt - mit einer 'Geheimlehre' vervindet, auszuloten. Eine textnah Interpretation seiner Aussagen zur apollinischen bzw. dionysischen Mysterienordung zeigt, dass die tragische griechische Kultur im Mysterienvorgang als kultischem un institutionellem Geschehen begründet ist. Aus Nietzsches Analyse dieser die Metaphysik des Willens exemplarisch zum Ausdruck bringenden Kultur geht hervor, (...) dass ohne Mysterien der Wille sich nicht optimal entfalten kann. Diese Einsicht überträgt Nietzsche auch in die Sprache seines Philosophierens.The aim of the article is to fathom the meaning of mystery cults in Nietzsche's early thinking. in a discreet manner, he associates the key concepts of his philosophy - the Apollonian and the Dionysian, the tragedy, the aesthetic justification of the world - with a 'secret doctrine'. A close reading of his writings on the Apollonian and Dionysian 'mystery order' shows that the tragic Greek culture is founded on the mysteris as cultic and institutional happenings. Nietzsche's analysis of this culture, which gives expression to the metaphysics of the will in an exemplary fashion, reveals that without mystery cults the will cannot unfold itself optimally . Nietzsche translates this insight also into the language of his philosophy. (shrink)

In the wake of the 1980 CSCE follow-up meeting US human rights objectives should be defined contextually so as to include besides the traditional human rights ingredients, i.e. the right to personal integrity, civil and politica! liberties, such values as peace, national security, nuclear non-proliferation, economie growth and redistribution. To this effect, the US should stress more a proper «world order» as its ultimate policy goal. Doing so would provide it at once with the flexibility needed in the international forum (...) and with the credibility needed on the domestic scene, in order to achieve some visible results. A high-pitched declaratory policy in favor of human rights leads to ineffectiveness with Communist nations and to arbitrary pressures on authoritarian countries which somehow rely on US assistance.Thus, the US should proceed contextually on the basis of a more balanced «human rights» concept. (shrink)

This paper seeks a deeper understanding of the congener as a factor in animal and human behaviour. It does so, not by concentrating on analyses of stimulus exchanges - largely specific to the species - by which a congener is recognized, but on the more general questions of why a notion of congener exists at all and why it plays such an extraordinary important role in animal and human behaviour.Three separate approaches, by way of anthropomorphic psychology, a paraphysical energy model (...) and the physical theory of the implicate order, lead to the recognition of a certain inseparability of self and congener; and to an interpretation of the content of the notion of congener and of the behaviour in relation to it, in terms of the fundamental concept of energy and the even more fundamental one of order. (shrink)

The sociobiological fashion has for a long time discouraged the development of theories of the immediate causation of behaviour. It is only recently that new approaches are being developed to improve on the classical ethological theory originated by Lorenz and Tinbergen. One new departure is behavioural field theory (BFT) which brings back the concept of energy in behaviour, without being susceptible to the drawbacks of the energy or fuel concept of classical theory. In this paper the new theory is explained (...) in some detail and it is shown to be illuminating, predictive and testable in examples of play-like and territorial behaviour. (shrink)

The paper tries to develop some of the main characteristics of Dilthey’s “phenomenology of metaphysics” in the second part of the Einleitung in die Geisteswissenschaften. It is argued that we have to understand this phenomenology as an attempt to go beyond both Kant’s and Comte’s criticism of metaphysics. According to Dilthey the core of all metaphysics is its ideal of a logical coherence of the world: in contrast to modern science, Dilthey says, metaphysics is based on the conviction that there (...) is an objective and internal coherence of reality behind the phenomena. Even if this coherence is reduced to its minimal form, that is to the combination of substantiality and causality, even then, Dilthey argues, it constitutes a projection of the living unity of human consciousness into extramental reality, and this prevents metaphysics from being science. Gradually the Christian metaphysics of the Middle Ages has been replaced by science, both in our knowledge of nature and in our knowledge of our spiritual self. Consequently metaphysics as a scientific project is for Dilthey a historical phenomenon, which irrevocably belongs to the past. The apparent completion of metaphysics in the ‘private metaphysical systems” of the Modern Age is in fact, Dilthey claims, the “euthanasia” of metaphysics, its unconscious noble and gentle suicide. For they conceive nature as a “colossal fantastic reflection of the metaphysician’s own self”, and in that way achieve a complete transformation of objective into subjective reality. By so doing, however, metaphysics destroys itself at the very moment of the complete fulfilment of its task. In the systems of Leibniz, Hegel etc. the old ideal of a total understanding of the world is apparently realised. But at the same time this means, according to Dilthey, that objective reality as such no longer exists. The total disclosure of the metaphysical secret is for Dilthey nothing else but the disclosure of the illusory nature of all metaphysics. (shrink)

Classical ethology, with its emphasis on separability of parts, has largely failed to do justice to the wholeness of the individual animal, to the integrity of group behaviour and to the continuity between observable behaviour and consciousness. Field theory has potentialities to do better, as illustrated in this paper with reference to morphogenetic and behavioural fields. A behavioural domain is delineated — playlike behaviour — where field theory is particularly relevant. It is shown that the concept of symmetry can suggest (...) new questions as well as explain some generally known phenomena of group behaviour. New interpretations of displacement activities and of etho-ecological adaptations are offered, both of which involve the whole individual animal. (shrink)

Displacement acts, once a hot topic in ethology, but wrapped in silence for two decades since, have recently been suggested to indicate and relax social tension (Maestripieri et al., 1992; Wiepkema, 1987). The first of these contentions seems to be in contradiction with some of the classical ethological studies of displacement behaviour, in particular those supporting the disinhibition hypothesis, since the latter would not predict any positive correlation between amount of tension (i.c. intensity of the conflict) and the occurrence of (...) displacement acts.A critical examination of these studies reveals that a positive correlation of the sort has been found, but that proponents of the disinhibition hypothesis tried to explain it in terms of their own model, rather than taking it at its face value. (The reason for this is that they viewed it as pleading for the surplus hypothesis which they rejected). It can be shown that at least some of their explanations are grounded on assumptions which are arbitrary. Also, the disinhibition hypothesis does not account for the occurrence of displacement behaviour in contexts with tension but without conflict. (shrink)

Locke & Bogin's (L&B's) main thesis can be extended to the acquisition of the phrasal vocabulary in that the acquisition of much phrasal vocabulary combines the acquisition of linguistic knowledge with pragmatics and performance and in that the apprenticeship system for such learning begins to flower in adolescence.

It is widely recognized that conceptual and theoretical innovations and the employment of new instruments and experimental techniques are important factors in explaining the growth of scientific knowledge in chemistry. This study examines another dimension of research in chemistry, collaboration and co-authorship. I focus specifically on Theodore Richards’ career and publications. During the period in which Richards worked, co-authorship was beginning to become more common than it had been previously. Richards was the first American chemist to be awarded a Nobel (...) Prize and he was at the forefront in this new trend in chemistry. He collaborated more than was typical for his time, with many scientists, in different sized groups, and he often had persistent collaborative relationships, extending over a number of years. Further, it appears that these collaborations benefited Richards, his collaborators, and the field of chemistry as a whole. (shrink)

“Doğal din” terimi, bazen doğanın kendisinin ilahi olduğu bir panteistik doktrine atıfta bulunur. “Doğal teoloji” terimi ise aksine, başlangıçta gözlemlenen doğal gerçekler temelinde (ve bazen) Tanrı’nın varlığını savunmaya yönelik projeye atıfta bulunur. Bununla birlikte çağdaş felsefede, hem “doğal din” hem de “doğal teoloji” genel olarak, dinî veya teolojik konuları araştırmak için insana, “doğal” olan bilişsel yetilerini – akıl, algı, içgözlem- kullanma projesini ifade eder. Doğal din veya teoloji, mevcut anlayış üzerine, doğayla ilgili ampirik araştırmalarla sınırlı olmamakla birlikte ayrıca panteistik bir (...) sonuçla da bağlantılı değildir. Bununla birlikte o, özel doğal olmayan yetilere (ESP, telepati, mistik deneyim) veya doğaüstü bilgi kaynaklarına (kutsal metinler, vahiy teolojisi, inanç otoriteleri, doğrudan doğaüstü iletişim) hitap etmekten kaçınır. Genel olarak, doğal din veya teoloji (bundan böyle “doğal teoloji” olarak anılacaktır), diğer felsefi ve bilimsel girişimlerle aynı rasyonel inceleme standartlarına uymayı amaçlamaktadır ve aynı değerlendirme ve eleştiri yöntemlerine tabidir. (shrink)

Astrolabes serving all latitudes are very rare. This recently rediscovered sixteenth-century Spanish example raises a host of questions which can only be addressed by considering all other such instruments and the few available textual sources. The instruments can all be traced back, not always directly, to an invention of the eleventh-century Andalusian astronomer Ali ibn Khalaf, preserved in the Old Castillian Libros del Saber de Astronomía of King Alfonso X. The design of this particular astrolabe and the engraving on it (...) are investigated in detail, and the as yet unidentified maker is associated with the circle around Juan de Herrera, architect of the palace-monastery of San Lorenzo de El Escorial. (shrink)

While ethical and empirical interest in so-called secondary variants and incidental findings in clinical genetics contexts is growing, critical reflection on the ethical foundations of the various recommendations proposed is thus far largely lacking. We examine and critique the ethical justifications of the three most prominent disclosure positions: briefly, the clinical geneticist decides, a joint decision, and the patient decides. Subsequently, instead of immediately developing a new disclosure option, we explore relevant foundational ethical values and norms, drawing on the normative (...) and empirical ethical literature. Four ethical signposts are thereby developed to help guide disclosure discussions. These are: respectful sharing of the clinician’s expertise; transparent communication; epistemic modesty; and respect for the embedded nature of the patient. We conclude by considering the most common current disclosure positions in the light of the four ethical signposts. (shrink)

Kadınların mukaddes görevlerini, insan neslinin devamlılığını sağlamayı yerine getirebilmelerine imkân veren aylık kanama dönemlerinin ironik bir şekilde kirlilik sebebi sayılması kadim bir anlayıştır. Her ne kadar feminist akımlarla beşeriyet tarihinin başlangıcındaki anaerkil dönemde kadınlara kutsallık katan doğurganlıklarının bir uzantısı olan adet görmelerinin, ataerkil düzene geçişle bir aşağılanma ve murdarlık sebebi sayılmaya başlandığı iddia edilmişse de bu görüş temellendirilebilir değildir. Tarihi süreçte kadınların regl dönemlerindeyken bereket ve şifa kaynağı görüldüklerinin de etrafına pislik bulaştıran bir murdarlık halinde kabul edildiklerinin de örnekleri bulunmak (...) mümkündür. Bununla birlikte hayızlı kadını kirli kabul eden anlayışın daha yaygın olduğu söylenebilir. Özellikle bu güne ulaşan şekliyle Yahudilikte, Cennette işlediği ilk günah sebebiyle cezalandırılmasının sonucu olarak adet gördüğü kabul edilen kadın, manen pistir. Bu pisliği dokunduğu her şeye bulaştırdığından tecrit edilmelidir. Kanaması bittiğinde temizlenmesi özel ritüellerle sağlanabilir. Zaten Yahudilikte kirlilik sebepleri ve kirliliğin toplumda yaygınlaşmaması için alınması gereken tedbirler konusu etrafındaki ahkâm, geniş ve karmaşıktır. Cüzzam hastalığına yakalanmakta kirlilik sebeplerindendir ve cüzzamlı da, özellikle din adamlarından, tecrit edilmelidir. Güncel Hristiyanlık, Yahudiliğin hayızlı kadınla ilgili düzenlemelerinin neredeyse uygulanamaz yükünden hepsini yok sayarak kurtulmuşsa da, ontolojik açıdan kadını ilk günahtan sorumlu tutma anlayışını genel olarak devam ettirmektedir. Cüzzamlıysa Hz. İsa (as) aracılığıyla tedavi edilerek Tanrı'nın rahmetinin ulaştığı bir konuma gelmiştir. İslam dini ise ilk günahı işlemede kadına ayrı bir sorumluluk yüklemediği gibi adet dönemini de bir kirlilik sebebi saymaz. Hz. Muhammed (as), hayızlı kadın hakkında indirilen ayetteki ifadeleri açıklarken, kadınları kirli kabul edip tecrit etmenin yanlış bir yorum olduğunu vurgulamıştır. Aksine bu dönemdeki kadınların temiz oldukları hakikatini hem sözleriyle hem de uygulamalarıyla göstermiştir. Sünnete uygun davranışın adetli eşle, tam bir cinsel birliktelik hariç, ilişkinin devam ettirilmesi olduğunu açığa çıkaran rivayetler çok sayıdadır. Öncellikle konuya ilk elden vakıf olan müminlerin annelerinden ve diğer sahabeden Hz. Peygamber'in hayızlı eşiyle aynı yatak ve yorganı kullanmaya, birlikte yiyip içmeye devam ettiğini; hayızlı kadının elinin, kan bulaşmadıkça giydiklerinin, tükürüğünün temiz olduğunu açıklayan bilgiler aktarılmaktadır. Yine de konu etrafındaki tartışma ve yanlış uygulamalar tabiîn döneminde devam etmiştir. Kadim inançların değişiminin zorluğu bu örnekte de açığa çıkmaktadır. Ayrıca kadınların aybaşı hali İslamî literatürde çoğunlukla fıkhi açıdan ele alınmıştır. Zira kadınların bu dönemde bulunması ibadetler ve muamelat açısından sonuçlar doğurmaktadır. Bu arada kadınla ilgili kökleri yaratılış anlatısına giden ontolojik suçluluğu ve cezayı hak ettiği inanışlarının Hz. Peygamber'in sünnetiyle ret edilmesinin önemi dikkatten kaçmaktadır. Kur'an'ın deyimiyle eza çeken kadına muhabbet ve ilgi gösterip desteklemenin sünnette vurgulanması da meselenin ihmal edilen bir yönüdür. Oysaki nasıl cüzzamlı Hz. İsa aracılığıyla uzak durulması gereken murdarlıktan Allah'ın bir peygamberi aracılığıyla şifa ulaştırılmasına layık kulu konumuna geldiyse, hayızlı kadın da Hz. Muhammed'in sünnetindeki uygulamayla birlikte yaşanacak manen temiz kişi konumuna getirilmiştir. (shrink)

L'A. esamina l'interpretazione della cosmogonia platonica nel sesto libro del De aeternitate mundi contra Proclum di Filopono. Lo studio propone inoltre un breve esame della questione della relazione fra filosofia aristotelica e platonica nel neoplatonismo greco.

Modal ontolojik argüman, Tanrı’nın varlığını sadece bilfiil gerçek olan bu dünyada değil, bütün mümkün dünyalarda göstermeye yönelik bir argümandır. Anselm’in (1033-1109) Proslogion adlı eserinin 3. bölümünde “kendisinden daha büyüğü düşünülemeyen” şeklinde tanımlanan; Tanrı’nın var olmamasının da düşünülemeyeceğini, bu yüzden de varolmamasının imkansızlığı üzerinde kurulu yeni bir argüman bulunduğunu öne süren bazı araştırmacılar, bu argümanı mümkün dünyalar semantiği yardımıyla formüle edip, “modal ontolojik argüman” şeklinde adlandırmışlardır. Çok farklı şekillerde formüle edilmiş bu argüman kabaca Tanrı’nın mümkünse zorunlu olması, dolayısıyla bilfiil gerçek olan (...) bu dünyada da var olması gerektiğini savunur. (shrink)

L’article se propose de vérifier le caractère néoplatonicien de la métaphysique d’Ammonius, fils d’Hermias, dans le dialogue intitulé Ammonius de Zacharie de Mytilène. Jusqu’à présent la recherche a cru pouvoir conclure de ce texte que la pensée d’Ammonius se rapprochait à certains égards du christianisme. Plusieurs éléments dans l’ Ammonius prouvent pourtant sans équivoque que le chef d’école alexandrin est resté fidèle au néoplatonisme païen, et notamment à la distinction proclusienne entre l’éternité divine et la perpétuité du monde.

Journal Name: Apeiron Issue: Ahead of print.

Çağdaş epistemoloji içerisinde, dışsalcı, güvenilirci ve erdeme dayalı epistemolojik tartışmaların bir benzerini, dini epistemoloji içerisinde etkili bir şekilde yer edinen ve reformcu epistemoloji olarak bilinen yaklaşım üzerinden görebilmek mümkündür. Alvin Plantinga, Nicholas Wolterstorff ve William Alston gibi filozofların öne çıktığı bu yaklaşımın ana iddiası, kanıta ya da argümana dayanmaksızın, Tanrı’nın varlığına inanmanın bütünüyle doğru, rasyonel, makul ve güvenilir olacağı şeklindeki bir tezdir. Kanıtın, gerekçelendirme için zorunlu bir koşul olmadığı fikri, algısal deneyimlerin gerekçelendirilmesine benzer şekilde, dini deneyimlerin de öyle olduğu ve (...) dolayısıyla, aynı epistemik statüye sahip olması gerektiğini öne süren, eşitlik tezine dayanır. İlk ortaya çıktığı günden bugüne, üzerinde çokça konuşulan ve tartışılan bir yaklaşım olan reformcu epistemoloji, özellikle son beş yıl içerisinde, oldukça farklı bir hale gelmiştir. Zira bu yaklaşımı, kanıtsalcılıkla uyumlu, erdem epistemolojisiyle bağlantılı ve diğer teistik dinler üzerinden değerlendiren yeni çalışmalar ortaya çıkmıştır. Bu nedenle, bu makalede, reformcu epistemoloji ana hatlarıyla ele alınmıştır. Beraberinde, ona yöneltilen itirazlara değinilmiş ve sonrasında, bahsi geçen yenilik iddiaları soruşturulmaya çalışılmıştır. Son olarak, teistik inancın rasyonalitesiyle ilgili, farklı bir bakış açısı sunulmuştur. (shrink)

Studies of epistemic communities and collaborative research in the social sciences have deepened the understanding of how science works, and more specifically how the social dimensions of scientific practice both enable and impede social scientists in realizing their epistemic goals. Two types of studies of epistemic communities are distinguished: general theories of epistemic communities aim to construct accounts of theoretical change applicable to all social scientific specialties, whereas historical studies emphasize the contingencies that affect specific social scientific disciplines, subfields, or (...) institutions. Although collaborative research plays a less pronounced role in the social sciences than in the natural sciences, collaboration has enabled social scientists to investigate topics that would otherwise be difficult to investigate. (shrink)

Philosophy has much to offer psychiatry, not least regarding ethical issues, but also issues regarding the mind, identity, values, and volition. This has become only more important as we have witnessed the growth and power of the pharmaceutical industry, accompanied by developments in the neurosciences. However, too few practising psychiatrists are familiar with the literature in this area. -/- The Oxford Handbook of Philosophy and Psychiatry offers the most comprehensive reference resource for this area ever published. It assembles challenging and (...) insightful contributions from key philosophers and others to the interactive fields of philosophy and psychiatry. Each contributions is original, stimulating, thorough, and clearly and engagingly written - with no potentially significant philosophical stone left unturned. Broad in scope, the book includes coverage of several areas of philosophy, including philosophy of mind, science, and ethics. For philosophers and psychiatrists, The Oxford Handbook of Philosophy and Psychiatry is a landmark publication in the field - one that will be of value to both students and researchers in this rapidly growing area. (shrink)

Mitos ve Logos kavramları Antik Yunan uygarlığında söz kavramına karşılık gelen sözcükleri karşılamak için kullanılmıştır. Felsefe tarihinin başlangıcı için yapılan tanımlamalarda ise mitos kavramının yerine logos kavramının tercih edilmesi iki kavram arasında bir farklılığı ortaya koymak için yapılmaktadır. Bu ayrımın nedeni ise mitos’un daha çok dinsel içerikle anılması logos’un ise içerisinde bir tür akılsallık barındırması şeklindeki yorumlarda kendini göstermektedir. Ancak söz konusu ayrımın ilk doğa filozofu/ilk felsefeci olarak nitelendirilen Thales için geçerli olup olmadığı geçmişte olduğu gibi günümüzde de halen tartışılmaktadır. (...) Felsefe tarihi yazımlarında ilk sıraya konan Thales’in anılan kavramları gerçekten farklı şekilde yorumlayıp yorumlamadığı bizce de tartışmaya açık bir husustur. Bu açıdan bakıldığında Thales, söz konusu kavramları iki farklı problemler alanı olarak mı görmüştür? Onun düşüncelerinde kendinden önceki mitolojik mirasın izleri bulunabilir mi? O, katışıksız bir rasyonel midir, yoksa henüz felsefenin yeni filizlendiği bir toplumda bir ara basamağı mı temsil etmektedir? Bu makalenin içerisinde tartışacağımız bu sorular, felsefe tarihinin başlangıcına ilişkin kavramsal arka planın ne olduğu hakkında bize katkı sağlayacaktır. (shrink)

The article examines Thomas Kuhn's work in the history of science with special attention to its relevance to subsequent developments in social epistemology. The article begins with a discussion of Kuhn's historical work, and the so-called historical turn in philosophy of science. It then examines Kuhn's views on textbook science, followed by an analysis of Kuhn's views on the relationship between the history of science and the philosophy of science. Then it discusses Kuhn's contributions to our understanding of the social (...) dimensions of scientific inquiry. Finally, it discusses his influence on the social epistemology of science and the sociology of science. (shrink)